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Tissue response to aqueous drainage in a functioning Molteno implant.

机译:功能正常的Molteno植入物中组织对房水引流的反应。

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摘要

The tissue reaction to a functioning Molteno implant has been studied by light microscopy and by scanning and transmission electron microscopy. The material was obtained from an aphakic 83-year-old human eye which required enucleation because of intractable bullous keratopathy, despite well controlled intraocular pressure. The tissue response around the silicone rubber tube was that of simple fibroblastic activity. Around the implant, however, there was fibrous tissue in which necrotic cell debris was prominent. No significant inflammation was observed in this tissue, but the choroid beneath the implant showed a focal inflammatory cell infiltrate. The morphology suggests that the tissue around all surfaces of the implant (450 mm2) is exposed to aqueous, which seems to have a toxic effect on the encapsulating connective tissue. The changes seen in the tissue exposed to draining aqueous are similar to those described in experimental studies of the effect of aqueous on cell growth in tissue culture.
机译:已通过光学显微镜以及扫描和透射电子显微镜研究了对功能正常的Molteno植入物的组织反应。该材料取自83岁的无晶状体人眼,尽管眼内压得到了很好的控制,但由于顽固的大疱性角膜病,仍需摘除眼球。硅橡胶管周围的组织反应是简单的成纤维细胞活性。然而,在植入物周围,有纤维组织,其中坏死细胞碎片突出。在该组织中未观察到明显的炎症,但植入物下方的脉络膜显示出局灶性炎症细胞浸润。形态表明,植入物所有表面(450平方毫米)周围的组织都暴露于水,这似乎对包裹的结缔组织具有毒性作用。在暴露于排水的水的组织中看到的变化与在组织培养中水对细胞生长的影响的实验研究中描述的变化相似。

著录项

  • 作者

    Loeffler, K U; Jay, J L;

  • 作者单位
  • 年度 1988
  • 总页数
  • 原文格式 PDF
  • 正文语种 en
  • 中图分类

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